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ORIGINAL ARTICLE
Year : 2020  |  Volume : 34  |  Issue : 2  |  Page : 82-84

Iris extramedullary hematopoiesis in choroidal melanoma


1 Ocular Oncology Service, Moorfields Eye Hospital; Ocular Oncology Service, St Bartholomew's Hospital, Helsinki, Finland
2 Ocular Oncology Service, Helsinki University Central Hospital, Helsinki, Finland
3 Institute of Ophthalmology, University College London, London, UK
4 Ocular Oncology Service, Moorfields Eye Hospital; Ocular Oncology Service, St Bartholomew's Hospital, Helsinki, Finland; Institute of Ophthalmology, University College London; NIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital and University College London, Institute of Ophthalmology, London, UK

Correspondence Address:
Dr. Victoria M L. Cohen
Ocular Oncology Service, Moorfields Eye Hospital, London EC1V 2PD

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1319-4534.305034

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PURPOSE: Extramedullary hematopoiesis (EMH) usually occurs in patients with loss of bone marrow hematopoietic function, and in a vast majority of cases, it involves the liver, the spleen, or the lymph nodes. We report EMH in the iris of patients enucleated for choroidal melanoma (CM). METHODS: We report a series of three patients with CM, two treated with primary enucleation and one with secondary enucleation. RESULTS: Histopathology revealed EMH in the iris of all patients. CONCLUSION: EMH of the iris can be associated with CM in the absence of any hematological or systemic disorders. To the best of our knowledge, our work is the first report of this abnormal histopathological finding.


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